How is conjugated bilirubin measured




















Article Navigation. Articles March 01 This Site. Google Scholar. Daniel W. Thomas, MD Daniel W. Thomas, MD. Pediatr Rev 28 3 : 83— Cite Icon Cite. After completing this article, readers should be able to:. Describe the metabolism of bilirubin. Evaluate a child of any age who has conjugated hyperbilirubinemia. Having a blood test with a needle carries some risks.

These include bleeding, infection, bruising, and feeling lightheaded. When the needle pricks your arm or hand, you may feel a slight sting or pain. Afterward, the site may be sore. Strenuous exercise and pregnancy can affect your results. Vitamin C, androgen hormones, and certain medicines, such as phenazopyridine and rifampin, can affect your results. You don't need to prepare for this test.

Tell your healthcare provider about all medicines, herbs, vitamins, and supplements you are taking. This includes medicines that don't need a prescription and any illegal drugs you may use. Search Encyclopedia. Direct Bilirubin Does this test have other names? Conjugated bilirubin What is this test? This test looks for bilirubin in your blood or urine. Why do I need this test? Signs and symptoms include: Yellowing of your skin and whites of your eyes jaundice Dark yellow-colored urine Light gray or clay-colored stools Nausea Vomiting Severe tiredness fatigue Belly pain or swelling You may also have this test to check for possible liver damage if you drink a lot of alcohol on a regular basis.

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Test for transferability. Comparison of five routine methods with the candidate reference method for the determination of bilirubin in neonatal serum. Clin Chem Lab Med ;— An assay for separating and quantifying four bilirubin fractions in untreated human serum using isocratic high-performance liquid chromatography. Clin Chim Acta ;— Clinical application of serum bilirubin fractionation by simplified liquid chromatography. Clin Chem ;—8. Determination of the sum of bilirubin sugar conjugates in plasma by bilirubin oxidase.

Reliability of transcutaneous bilirubin devices in preterm infants: a systematic review. Pediatrics ;— Hyperbilirubinemia and transcutaneous bilirubinometry. Clin Chem ;—7. Interferencias en el analisis de orina con tiras multirreactivas: comision de interferencias y efectos de los medicamentos en bioquimica clinica.

Quim Clin ;— Rev Del Lab Clin ;— Reference measurement procedure for total bilirubin in serum re-evaluated and measurement uncertainty determined. The status of bilirubin measurements in U. Laboratories: why is accuracy elusive? Semin Perinatol ;—7. Bovine serum-based bilirubin calibrators are inappropriate for some diazo methods. A global multicenter study on reference values: 1. Assessment of methods for derivation and comparison of reference intervals.

Hepatic accumulation and intracellular binding of conjugated bilirubin. J Clin Invest ;—9. Bilirubin as a biomarker in liver disease. In: Biomarkers in liver disease. Hepatic storage and excretion of bilirubin in man. Sticova, E, Jirsa, M. New insights in bilirubin metabolism and their clinical implications. World J Gastroenterol ;— Development of an accurate index for predicting outcomes of patients with acute liver failure. A systematic review on prognostic indicators of acute on chronic liver failure and their predictive value for mortality.

Noninvasive assessment of liver function. Curr Opin Gastroenterol ;— J Hepatol ;— Prognostic value of the albumin—bilirubin grade in patients with hepatocellular carcinoma and other liver diseases. Ann Transl Med ; Bilirubin alone as a biomarker for short-term mortality in acute-on-chronic liver failure: an important prognostic indicator. Ann Hepatol ;— Serum bilirubin and risk of ischemic heart disease in middle-aged British men. Serum bilirubin and cardiovascular risk factors in a Chinese population.

J Cardiovasc Risk ;— Serum bilirubin distribution and its relation to cardiovascular risk in children and young adults. Abstract Bilirubin fractions are measured by 1 the direct diazo reaction, 2 high-performance liquid chromatography HPLC , 3 direct spectrophotometry, and 4 enzymatic methods.

Publication types Comparative Study Review.



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